BOX_m - rented back . . .
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Program and Schedule
| | InnovationWell InterAction Meeting at Bryn Mawr, Philadelphia (12-16 October 2009) |
MONDAY 12 OCTOBER
07.30 Registration & Welcome Coffee Opens, Thomas Great Hall, Bryn Mawr College
Forum on Collaboration in Discovery and Development, Co-chaired by Peter Gates (Johnson & Johnson PR&D) and Barry Hardy (Douglas Connect)
More Information on Session including Abstracts and Biographies....
[Thomas room 110]
09.00 Introductions and Overview
09.15 Barry Hardy (Douglas Connect), Knowledge-oriented Support of Virtual Organisations
09.45 Shree Nath (Pointcross), Contextual Knowledge Environments to Unify R&D Processes, Data Flows and Collaboration
10.15 Coffee Break
10.45 Simson Alex (Johnson & Johnson), The ABCDs of Experimental Data
11.15 Chris Waller (Pfizer), The Pistoia Alliance, Inc. – A Construct for Precompetitive Collaboration
11.45 Knowledge Cafe on Perspectives [Thomas Great Hall]
13.00 Lunch
14.00 Michael Liebman (Strategic Medicine), Drug Development Across the Healthcare Ecosystem
14.30 Jeff Spitzner (Rescentris), Managing Collaborative Research Projects in Distributed Research Organizations
15.00 Bob O’Hara (ResultWorks), R&D Knowledge Management – Technology Initiative or Business Fundamental?
15.30 Coffee Break
16.00 Knowledge Cafe on Perspectives [Thomas Great Hall]
18.30 Refreshments & Dinner [Wyndham Alumnae House]
TUESDAY 13 OCTOBER
Translational Bioinformatics: Bridging Bioinformatics and Biomedical Informatics in Translational Medicine, Chaired by Jake Chen (Indiana University)
More Information on Session including Abstracts and Biographies....
[Thomas room 110]
09.00 Chair’s Introduction & Opening Remarks
09.15 Jessica Tenenbaum (Duke Translational Medicine Institute, Duke University), The MURDOCK Study: An Inter-omics Approach to Reclassifying Disease through Biomarker Discovery
09.40 Steve Naylor (Predictive Physiology and Medicine, Inc.), Title TBA
10.05 Javed Mostafa (University of North Carolina), Medical Image Content-based Retrieval for Clinical Decision Support
10.30 Coffee Break
11.00 Jay Zhang (Myriad Genetics), Developing and Commercializing Personalized Medicine: Business Challenges, and Regulatory and IP Risks
11.25 Maricel Kann (University of Maryland), Using Correlated Evolution of Interacting Protein Domains to Predict their Interactions
11.50 Iya Khalil (Gene Network Sciences), Optimizing Causal Drug Target and Marker Discovery with the GNS Supercomputer-Driven REFSâ„¢ Platform
12.15 Panel Discussion
13.00 Lunch
14.00 Hai Hu (Windber Research Institute), Biomedical Informatics in Translational Research
14.25 Jake Chen (Indiana University – Purdue University), Translational Bioinformatics in Genome Medicine
14.50 Susan Stephens (Johnson & Johnson), Answering Translational Questions in Neuroscience Using Linked Data Techniques
15.15 Panel Discussion
15.45 Coffee Break
16.15 Knowledge Cafe on Perspectives [Thomas Great Hall]
18.30 Poster Session, Refreshments and Food [Thomas Great Hall]
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WEDNESDAY 14 OCTOBER
Systems Biology and Biomarkers, Chaired by Darius Dziuda (Central Connecticut State University)
More Information on Session including Abstracts and Biographies....
[Thomas room 110]
09.00 Chair’s Introduction & Opening Remarks
09.15 Anamika Sarkar (Novartis), Disease Modeling and its Applications in Model-based Drug R&D: the Example of an Integrated Model of Hypertension, Renal Disease Progression and Therapeutic Modulation of the Renin-Angiotensin-Aldosterone System (RAAS)
09.50 Darius Dziuda (Central Connecticut State University), Identifying Primary Sets of Informative Genes via a Modified Bagging Approach
10.25 Coffee Break
10.55 Frank Tobin (Tobin Consulting LLC), Mathematical (Computational) Systems Biology: Opportunities and Challenges
11.30 Usha Reddy (Merck), Impact of Data Standards in Translational Research and Biomarker Discovery
12.05 Panel Discussion
13.00 Lunch
Modeling of the Blood–Brain Barrier in Drug Discovery and Development, Chaired by Roméo Cecchelli (Université d'Artois, France)
More Information on Session including Abstracts and Biographies....
[Thomas room 110]
14.00 Chair’s Introduction & Opening Remarks
14.10 Stefan Lundquist (AstraZeneca), The Blood-Brain Barrier in the CNS Drug Discovery Process
14.35 Reinhard Gabathuler (AngioChem), Angiopeps: a New Peptide Family for the Transport of Small and Large Molecules to the Brain
15.00 Maxime Culot (University of Lille), In vitro Blood-Brain Barrier Models for High Throughput Toxicological Screening
15.25 Coffee Break
15.55 Damir Janigro (Cleveland Clinic Foundation), Drug Metabolism at the Human Epileptic Blood-Brain Barrier: In situ and in vitro
16.20 Marie-Pierre Dehouck (University of Lille), Cell-cell interaction at the Neurovascular Unit (NVU) in Physiological and Pathological Conditions
16.45 Pierre-Olivier Couraud (Institut Cochin), An Immortalized Human Brain Endothelial Cell Line as a Model of Human Blood-Brain Barrier for Drug Screening and Pharmacological studies
17.10 Anna Seelig (University of Basel), Experimental and Computational Prediction of Blood-Brain Barrier Permeation
17.35 Panel Discussion
18.30 Poster Session, Refreshments and Food [Thomas Great Hall]
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THURSDAY 15 OCTOBER
Predictive Toxicology: Combining in vitro and in silico Techniques in Predictive Toxicology Applications, Co-chaired by Richard Judson (US EPA) and Vladimir Poroikov (Institute of Biomedical Chemistry of Russian Academy of Medical Sciences)
More Information on Session including Abstracts and Biographies....
[Thomas room 110]
09.00 Chair’s Introduction & Opening Remarks
09.15 Richard Judson (US EPA), High Throughput Screening of Toxicity Pathways Perturbed by Environmental Chemicals
09.40 Ellen Berg (BioSeek), Defining Chemical Target and Pathway Toxicity Mechanisms with Primary Human Cell Systems
10.15 Peter Elkin (Mount Sinai School of Medicine, New York), eQuality for All: Extending Automated Quality Measurement of Free Text Clinical Narratives
10.40 Coffee Break
11.10 Barry Hardy (Douglas Connect), Integrated Predictive Toxicology Application Development
11.35 Sanji Bhal (ACD/Labs), Applications of GALAS Modeling Methodology for the Prediction of Drug Safety Related Properties. Evaluation and Expansion of the Model Applicability Domain
12.00 Christodoulos Floudas (Princeton University), Predicting in vivo Toxicities using Optimal Methods for Re-ordering and Logistic Regression
12.25 Panel Discussion
13.00 Lunch
14.00 Kyoung Tai No (Yonsei University), In Silico Prediction of Drug Metabolism in the Liver
14.25 Robert Fraczkiewicz (Simulations Plus), Modeling Rat Liver Toxicity Signature Using Machine Learning Techniques
14.50 Stephen Bryant (NIH), Toxicology Data Sets in PubChem
15.15 Panel Discussion
15:45 Coffee Break
16.15 Knowledge Cafe [Thomas Great Hall]
18.30 Refreshments and Food [Thomas Great Hall]
FRIDAY 16 OCTOBER
Predictive Toxicology: Combining in vitro and in silico Techniques in Predictive Toxicology Applications, Co-chaired by Richard Judson (US EPA) and Vladimir Poroikov (Institute of Biomedical Chemistry of Russian Academy of Medical Sciences)
More Information on Session including Abstracts and Biographies....
[Thomas room 110]
09.00 Chair’s Introduction & Opening Remarks
09.15 Vladimir Poroikov (Institute of Biomedical Chemistry of Russian Academy of Medical Sciences), QSAR Modeling of Toxicity: Comparison of Pharmaceutical and Industrial Chemicals
09.40 Fangping Mu (Los Alamos National Laboratory), Computational Xenobiotics Metabolism Prediction System
10.05 Katya Tsaioun (Apredica), In vitro Models that Predict Major Known Mechanisms of Human Toxicity. Validation, Case Studies and Path Forward
10.30 Coffee Break
11.00 Grace Patlewicz (DuPont), Read-across – a Data Gap Filling Technique – Help or Hindrance? A Practical Perspective
11.25 Michael Pelekis (Simulations Plus), Not Just 'If' or 'Where', but Also 'How Fast' – Predictive Modeling of Kinetic Constants for CYP-Mediated Metabolism
11.50 Anil Aswani (University of California at Berkeley), A Network-Level Approach to Predictive Toxicology
12.15 Panel Discussion
13.00 Lunch
Close of Program
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